Microphysiological System Device for Hypoxic Organ Injury Drug Efficacy Evaluation

Traditional drug efficacy evaluation relies on animal experiments, which have long cycle, high cost and species difference limitations. This study constructs a novel microphysiological system medical device for simulating human intestinal and liver hypoxic injury. The device builds a bionic human organ microenvironment in vitro, which can accurately simulate the pathological changes of intestinal and liver dysfunction under hypoxic conditions. It can be used for high-throughput screening and efficacy verification of protective drugs for organ injury, providing a low-cost, high-precision in-vitro evaluation platform for preclinical drug research and biomedical material testing.